Abstract. Introduction. Subjects and Methods. Results. Discussion. Conclusion. References. Article Figures. With regard to biocompatibility, two articles showed biodentine to be better and two showed comparable results, while in the case of sealing ability, one article. The article provides an overview of Biodentine clinical applications summarizing published clinical trials and reporting published clinical cases with this material.

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Related articles Apexification apical barrier Biodentine periradicular healing. Life Sci J ; Though the information accumulated so far regarding the biocompatibility of Biodentine is rather limited, the available data generally is in favor of the material in terms of its lack of cytotoxicity and tissue acceptability. The liquid, on the other hand, contains calcium chloride as an accelerator and a hydrosoluble polymer that serves as a water reducing agent.

J Interdiscipl Med Dent Sci 2: Published online Aug 1. The reason for such a preference might be due to some study results which show that zirconium oxide possesses biocompatible characteristics and is indicated as a bioinert material with favorable mechanical properties and resistance to corrosion [ 27 ]. Biodentine favorably affected healing when placed directly in contact with the pulp by enhancing the proliferation, migration, and adhesion of human dental pulp stem cells, confirming the bioactive and biocompatible characteristics of the material [ 42 ].

The authors described that this methodology uses a Vicat apparatus with a needle of specific mass.

MTA versus Biodentine: Review of Literature with a Comparative Analysis

In reconstituted saliva containing phosphatesno erosion has been observed. Similarly, Nunez CMC et al. Another consideration should be made based on the clinical scenarios where Biodentine is intended to be used.

A prospective clinical study of periradicular surgery using mineral trioxide aggregate as a root-end filling.

Difficult handling Mooney GC and North S [ 62 ] observed that the manipulation of MTA was messy when the moisture was excessive in the preparation which further results in soupy material and hence difficult to use Discoloration Accorinte ML et al.

Mineral trioxide aggregate MTAa bioactive cement with excellent sealing ability and biocompatibility is capable of regenerating relatively damaged pulp and formation of dentin bridge when used as DPC agent. The review initially focuses on various physical properties of the material with subheadings and continues with biocompatibility.


Biodentine was further described as having calcium carbonate in powder and the carbonate phase of the material was verified by XRD and FT-IR articlfs. It has also been stated that fast viodentine time, one unique characteristics of the product, is achieved by increasing particle size, adding calcium chloride to the liquid component, and decreasing the liquid content.

The effect of several root end filling materials on MG63 osteoblast like cells. Response of human dental pulp cappedwith MTA and calcium hydroxide powder.

An immature tooth with pulpal necrosis and periapical pathology imposes a great difficulty to the endodontist. A comparative study of using a combination of calcium chloride and mineral trioxide aggregate as biodentinf pulp-capping agent on dogs’ teeth.

Therefore, both papers are not comparable. De Souza ET et al.

Biodentine versus mineral trioxide aggregate versus intermediate restorative material for retrograde root end filling: One study evaluated Biodentine from this perspective where Biodentine, along with 4 different materials, was exposed to different oxygen and light conditions and spectrophotometric analysis was performed at different periods until 5 days [ 35 ].

Biodentine material has been recently introduced in dentistry in order to provide dentin substitute for coronal and radicular pulp.

A Review on Biodentine, a Contemporary Dentine Replacement and Repair Material

Aust Dent J ; Treatment of a non-vital immature incisor with mineral trioxide aggregate MTA. The first study to demonstrate the induction of effective dentinal repair was the one by Tran et al. Whilst the cavity adaptation of bioglass was poor owing to its particle size, both glass ionomers and calcium silicate cements yielded favorable results as dentine substitutes. Bioactivity and Regenerative Potential Laurent P et al. Porosity has been shown to have an impact upon numerous other factors including adsorption, permeability, strength, and density.

Is this a reality? They showed that both bBodentine and MTA involved in early odontoblastic differentiation and initiation of mineralisation and thus form reparative dentin synthesis then other two materials. J Oral Res Rev ;7: One such study performed by Camilleri J et al. Their results showed that the 24 h push-out strength of MTA was less than that of Biodentine and blood contamination affected the push-out bond strength of MTA Plus irrespective of the setting time. It has further been stated that the maximum pore diameter, which corresponds to the largest leak in the sample, along with bacterial size and their metabolites, will be indicative of the leakage that occurs along the root-end filling materials [ 19 ].


This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Characterisation of dental pulp stem cells: In cases where there is direct contact with bioedntine surrounding connective tissue, biocompatibility is of primary significance. A comparative histological analysis of human pulp following direct pulp capping with propolis, mineral trioxide aggregate and Dycal.

Find articles by Jaidev Singh Dhillon. SiO 2 includes four elements: August 11, Citation: Table of Contents Alerts. For the determination of the radiopacities of filling materials, the method developed by Tagger and Katz [ 26 ] is generally used where radiographic images of the material are taken alongside an aluminium step-wedge.

Chemical, physical, and antibacterial properties.

BioMed Research International

While referring to the loss of dentin in the coronal part, such as in case of deep carious lesions, materials like Glass-Ionomer Cement have been used extensively, but with its limitation of not stimulating any reparative dentin formation on its own [ 1 ]. E J Dent ;2: Emerging trends in bio material research Artkcles — chemical properties of Biodentine.

These should further be supported by clinical trials to establish a clear picture regarding the general characteristics of the materials. None, Conflict of Interest: In order to overcome these limitations, a new bioceramic material named Biodentine was introduced in the artjcles of which has proved to be a second major break-through.